2. Academic Validation
  3. Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

  • Chem Commun (Camb). 2017 Aug 3;53(63):8910-8913. doi: 10.1039/c7cc05159j.
Pawan Kumar 1,  Afaf H El-Sagheer 2,  Lynda Truong 1,  Tom Brown 1
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk.
  • 2 Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk and Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt.
PMID: 28748236 DOI: 10.1039/c7cc05159j
Abstract

Oligonucleotides containing internal triazole-3'-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified Oligonucleotides, and significantly better than Oligonucleotides containing triazole alone. In contrast LNA on the 5'-side of the triazole does not stabilise duplexes. Triazole-LNA confers great resistance towards enzymatic degradation relative to LNA alone.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z