2. Academic Validation
  3. The anticoagulant activity of some selected warfarin analogues

The anticoagulant activity of some selected warfarin analogues

  • J Pharm Pharmacol. 1987 Feb;39(2):142-4. doi: 10.1111/j.2042-7158.1987.tb06964.x.
A O Obaseki,  H B Coker
PMID: 2882003 DOI: 10.1111/j.2042-7158.1987.tb06964.x
Abstract

The anticoagulant activities of 6-, 7-, 8-, 4'-hydroxy, 6-chloro- and 6-bromowarfarin were determined in rabbits after intraperitoneal administration of 16.2 mumol kg-1 over 96 h. Substitution on the 4-hydroxycoumarin moiety resulted in reduction of the anticoagulant activity. 6-Chlorowarfarin was more potent than 6-bromowarfarin suggesting that the molecular size of 4-hydroxycoumarin moiety may be crucial for biological activity.

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