2. Academic Validation
  3. The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5+CD1dhiFcγRIIbhi Regulatory B-Cell Subset in Lupus

The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5+CD1dhiFcγRIIbhi Regulatory B-Cell Subset in Lupus

  • J Invest Dermatol. 2017 Dec;137(12):2532-2543. doi: 10.1016/j.jid.2017.07.843.
Yamin Zhang 1,  Jun Li 2,  Nuoya Zhou 1,  Yi Zhang 1,  Min Wu 3,  Jian Xu 4,  Chen Shen 1,  Xiangjie An 1,  Guanxin Shen 3,  Ming Yang 5,  Chun Zhang 6,  Juan Tao 7
Affiliations

Affiliations

  • 1 Department of Dermatology, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, Hubei, China.
  • 2 Department of Dermatology, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, Hubei, China; Department of Dermatology, The Central Hospital of Wuhan, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, Hubei, China.
  • 3 Department of Immunology, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, Hubei, China.
  • 4 Department of Hematology, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, Hubei, China.
  • 5 Department of Dermatology, The Central Hospital of Wuhan, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, Hubei, China.
  • 6 Department of Nephrology, Union Hospital, Tongji Medical College, HUST, Wuhan, Hubei, China.
  • 7 Department of Dermatology, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: tjhappy@126.com.
PMID: 28844943 DOI: 10.1016/j.jid.2017.07.843
Abstract

IL-35 is a critical immunosuppressive cytokine that plays an important role in various autoimmune diseases. The purpose of this study was to determine whether BAFF, a key pathogenic factor in systemic lupus erythematosus, also a dichotomous regulator for B-cell immune responses, has an effect on IL-35-producing regulatory B cells and their underlying mechanisms in lupus. We found that exogenous BAFF could induce IL-35 production by splenic B cells from MRL-Faslpr/lpr mice. BAFF-induced IL-35-producing B cells were mainly from the marginal zone B-cell subset and exhibited a CD5+CD1dhiFcγRIIbhi phenotype. These IL-35-producing regulatory B-cell subsets exhibited regulatory effects on both CD4+CD25- T cells and CD4+CD25+ regulatory T cells. We further identified that BAFF-TACI interaction could induce the production of IL-35 through the classical NF-κB1 pathway. In vivo study also showed that BAFF could facilitate IL-35 secretion in marginal zone B cells, whereas anti-BAFF treatment could decrease the frequency of IL-35-producing CD5+CD1dhiFcγRIIbhi B cells in MRL-Faslpr/lpr mice. We showed that BAFF could induce IL-35 production by a unique CD5+CD1dhiFcγRIIbhi regulatory B-cell subset mainly through TACI activation in lupus, providing an advanced understanding of the regulatory effect of BAFF in autoimmune diseases.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-15473
    99.76%, IKKβ 抑制剂
    IKK
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z