2. Academic Validation
  3. An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

  • Eur J Med Chem. 2017 Dec 15:142:328-375. doi: 10.1016/j.ejmech.2017.08.009.
Stella Cascioferro 1,  Barbara Parrino 1,  Virginia Spanò 1,  Anna Carbone 1,  Alessandra Montalbano 1,  Paola Barraja 1,  Patrizia Diana 1,  Girolamo Cirrincione 2
Affiliations

Affiliations

  • 1 Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
  • 2 Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy. Electronic address: girolamo.cirrincione@unipa.it.
PMID: 28851503 DOI: 10.1016/j.ejmech.2017.08.009
Abstract

The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,N'-dioxides as well as the benzo- and hetero-fused systems are reported. Herein are treated derivatives disclosed to literature from the beginning of this century up to 2016. Among the three possible triazine isomers, 1,2,4-triazines are the most studied ones and many derivatives having remarkable antitumor activity have been reported in the literature and also patented reaching advanced phases of clinical trials.

Keywords

1,2,4-benzotriazine; 1,2,4-triazine; Antiproliferative activity; Antitumor activity; Nitrogen heterocycles.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z