2. Academic Validation
  3. H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma

H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma

  • Cancer Res. 2017 Dec 15;77(24):6999-7013. doi: 10.1158/0008-5472.CAN-17-1865.
Jaya Julie Joshi 1,  Heather Coffey 1,  Erik Corcoran 1,  Jennifer Tsai 1,  Chia-Ling Huang 1,  Kana Ichikawa 1,  Sudeep Prajapati 1,  Ming-Hong Hao 1,  Suzanna Bailey 1,  Jeremy Wu 1,  Victoria Rimkunas 1,  Craig Karr 1,  Vanitha Subramanian 1,  Pavan Kumar 1,  Crystal MacKenzie 1,  Raelene Hurley 1,  Takashi Satoh 1,  Kun Yu 1,  Eunice Park 1,  Nathalie Rioux 1,  Amy Kim 1,  Weidong G Lai 2,  Lihua Yu 1,  Ping Zhu 1,  Silvia Buonamici 1,  Nicholas Larsen 1,  Peter Fekkes 1,  John Wang 1,  Markus Warmuth 1,  Dominic J Reynolds 1,  Peter G Smith 3,  Anand Selvaraj 3
Affiliations

Affiliations

  • 1 H3 Biomedicine, Cambridge, Massachusetts.
  • 2 Eisai, Andover, Massachusetts.
  • 3 H3 Biomedicine, Cambridge, Massachusetts. anand_selvaraj@h3biomedicine.com peter_smith@h3biomedicine.com.
PMID: 29247039 DOI: 10.1158/0008-5472.CAN-17-1865
Abstract

Activation of the Fibroblast Growth Factor receptor FGFR4 by FGF19 drives hepatocellular carcinoma (HCC), a disease with few, if any, effective treatment options. While a number of pan-FGFR inhibitors are being clinically evaluated, their application to FGF19-driven HCC may be limited by dose-limiting toxicities mediated by FGFR1-3 receptors. To evade the potential limitations of pan-FGFR inhibitors, we generated H3B-6527, a highly selective covalent FGFR4 Inhibitor, through structure-guided drug design. Studies in a panel of 40 HCC cell lines and 30 HCC PDX models showed that FGF19 expression is a predictive biomarker for H3B-6527 response. Moreover, coadministration of the CDK4/6 inhibitor palbociclib in combination with H3B-6527 could effectively trigger tumor regression in a xenograft model of HCC. Overall, our results offer preclinical proof of concept for H3B-6527 as a candidate therapeutic agent for HCC cases that exhibit increased expression of FGF19. Cancer Res; 77(24); 6999-7013. ©2017 AACR.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-100491
    ≥98.0%, FGFR4 抑制剂
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