2. Academic Validation
  3. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)

Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)

  • Molecules. 2017 Dec 21;23(1):13. doi: 10.3390/molecules23010013.
Ariane Dolly Kenmogne Kouam 1 2,  Achille Nouga Bissoue 3,  Alain Tadjong Tcho 4,  Emmanuel Ngeufa Happi 5,  Alain François Kamdem Waffo 6,  Norbert Sewald 7,  Jean Duplex Wansi 8
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. arydolls@gmail.com.
  • 2 Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany. arydolls@gmail.com.
  • 3 Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. anbissoue@yahoo.fr.
  • 4 Department of Chemistry, University of Buea, Faculty of Sciences, 63 Buea, Cameroon. alainstone1@yahoo.fr.
  • 5 Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. ngeufa@yahoo.fr.
  • 6 Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. akamdemfr@yahoo.fr.
  • 7 Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany. norbert.sewald@uni-bielefeld.de.
  • 8 Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. jdwansi@yahoo.fr.
PMID: 29267257 DOI: 10.3390/molecules23010013
Abstract

Three new prenylated furoquinoline Alkaloids named lecomtequinoline A (1), B (2), and C (3), together with the known compounds anhydroevoxine (4), evoxine (5), dictamnine (6), N-methylflindersine (7), evoxanthine (8), hesperidin, lupeol, β-sitosterol, stigmasterol, β-sitosterol-3-O-β-d-glucopyranoside, stearic acid, and myristyl alcohol, were isolated by bioassay-guided fractionation of the methanolic extracts of leaves and stem of Vepris lecomteana. The structures of compounds were determined by spectroscopic methods (NMR, MS, UV, and IR) and by comparison with previously reported data. Crude extracts of leaves and stem displayed high antimicrobial activity, with Minimum Inhibitory Concentration (MIC) (values of 10.1-16.5 and 10.2-20.5 µg/mL, respectively, against Escherichia coli, Bacillus subtilis, Pseudomonas agarici, Micrococcus luteus, and Staphylococcus warneri, while compounds 1-6 showed values ranging from 11.1 to 18.7 µg/mL or were inactive, suggesting synergistic effect. The extracts may find application in crude drug preparations in Western Africa where Vepris lecomteana is endemic, subject to negative toxicity results in vivo.

Keywords

Vepris lecomteana; furoquinoline alkaloids; lecomte quinoline A–C.

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