2. Academic Validation
  3. GE11 Peptide as an Active Targeting Agent in Antitumor Therapy: A Minireview

GE11 Peptide as an Active Targeting Agent in Antitumor Therapy: A Minireview

  • Pharmaceutics. 2017 Dec 22;10(1):2. doi: 10.3390/pharmaceutics10010002.
Ida Genta 1,  Enrica Chiesa 2,  Barbara Colzani 3,  Tiziana Modena 4,  Bice Conti 5,  Rossella Dorati 6
Affiliations

Affiliations

  • 1 Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. ida.genta@unipv.it.
  • 2 Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. enrica.chiesa01@gmail.com.
  • 3 Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. barbara.colzani@unipv.it.
  • 4 Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. tiziana.modena@unipv.it.
  • 5 Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. bice.conti@unipv.it.
  • 6 Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. rossella.dorati@unipv.it.
PMID: 29271876 DOI: 10.3390/pharmaceutics10010002
Abstract

A lot of solid tumors are characterized by uncontrolled signal transduction triggered by receptors related to cellular growth. The targeting of these cell receptors with antitumor drugs is essential to improve chemotherapy efficacy. This can be achieved by conjugation of an active targeting agent to the polymer portion of a colloidal Drug Delivery system loaded with an antitumor drug. The goal of this minireview is to report and discuss some recent results in epidermal growth factor receptor targeting by the GE11 peptide combined with colloidal Drug Delivery systems as smart carriers for antitumor drugs. The minireview chapters will focus on explaining and discussing: (i) Epidermal growth factor receptor (EGFR) structures and functions; (ii) GE11 structure and biologic activity; (iii) examples of GE11 conjugation and GE11-conjugated Drug Delivery systems. The rationale is to contribute in gathering information on the topic of active targeting to tumors. A case study is introduced, involving research on tumor cell targeting by the GE11 peptide combined with polymer nanoparticles.

Keywords

EGFR; GE11; antitumor drug; colloidal drug delivery systems; drug targeting; nanomedicine.

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