2. Academic Validation
  3. Activity of the pterophyllins 2 and 4 against postharvest fruit pathogenic fungi. Comparison with a synthetic analog and related intermediates

Activity of the pterophyllins 2 and 4 against postharvest fruit pathogenic fungi. Comparison with a synthetic analog and related intermediates

  • Fitoterapia. 2018 Mar:125:98-105. doi: 10.1016/j.fitote.2017.12.021.
Jorgelina L Pergomet 1,  Melina G Di Liberto 2,  Marcos G Derita 3,  Andrea B J Bracca 4,  Teodoro S Kaufman 5
Affiliations

Affiliations

  • 1 Instituto de Química Rosario (IQUIR, CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina.
  • 2 Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina.
  • 3 Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina; CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, S3080HOF, Esperanza, Argentina.
  • 4 Instituto de Química Rosario (IQUIR, CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina. Electronic address: bracca@iquir-conicet.gov.ar.
  • 5 Instituto de Química Rosario (IQUIR, CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina. Electronic address: kaufman@iquir-conicet.gov.ar.
PMID: 29288027 DOI: 10.1016/j.fitote.2017.12.021
Abstract

The Antifungal activity of pterophyllin 2, pterophyllin 4, a 5-desmethyl analog of the latter and some of their synthetic intermediates, against three postharvest phytopathogenic fungi, was evaluated. The target fungi were Rhizopus stolonifer, Botrytis cinerea and Monilinia fructicola, which affect fruits worldwide, causing important economic losses. The tests were carried out with imazalil and carbendazim as positive controls. Minimum inhibitory concentrations and minimum fungicidal concentrations were determined, and the morphology of the colonies was examined microscopically. In liquid medium, it was found that pterophyllin 4 exhibited selective fungicidal activity toward M. fructicola, whereas its congener pterophyllin 2 proved to be less potent and not selective and the 5-desmethyl analog of pterophyllin 4 displayed a different activity profile. Morphological changes were observed in the colonies exposed to pterophyllin 4. The results highlighted the importance of small structural features for the Antifungal behavior and also suggested that, in Nature, the pterophyllins may act as plant defenses against pathogens.

Keywords

Antifungal activity; Bioactive furocoumarins; Fruit phytopathogens; Morphological changes; Natural product analog; Pterophyllins 2 and 4.

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