2. Academic Validation
  3. 7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs

7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs

  • Bioorg Med Chem Lett. 2018 Apr 1;28(6):1084-1089. doi: 10.1016/j.bmcl.2018.02.014.
Tae Kyoung Lee 1,  Jun Yeon Park 2,  Jae Sik Yu 1,  Tae Su Jang 3,  Seong Taek Oh 4,  Changhyun Pang 5,  Yoon-Joo Ko 6,  Ki Sung Kang 7,  Ki Hyun Kim 8
Affiliations

Affiliations

  • 1 School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • 2 College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea.
  • 3 Institute of Green Bio Science & Technology, Seoul National University, Pyeong Chang 232-916, Republic of Korea.
  • 4 College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
  • 5 School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
  • 6 Laboratory of Nucear Magnetic Resonance, National Center for Inter-University Research Facilities (NCIRF), Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.
  • 7 College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea. Electronic address: kkang@gachon.ac.kr.
  • 8 School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: khkim83@skku.edu.
PMID: 29459209 DOI: 10.1016/j.bmcl.2018.02.014
Abstract

Pinus koraiensis pinecones are considered an undesired waste by-product of the processing of seeds. However, recent studies of the potential anti-tumor effects of the pinecones have led to increasing interest in their chemical constituents. The present study examined the potential antiangiogenic effects of the constituents of pinecones and further characterized their underlying mechanisms of action. Chemical investigation of a water extract of P. koraiensis pinecones led to the isolation and identification of the eight main components including five Diterpenoids (1-5), two monoterpenes (6,7) and a phenolic acid (8). The structure of the compounds was determined by spectroscopic analysis of NMR spectra and LC/MS analysis. Of the isolated compounds, 7α,15-dihydroxydehydroabietic acid (5) significantly inhibited the promotion of angiogenesis in human umbilical vein endothelial cells (HUVECs). Compound 5 inhibited angiogenesis through downregulation of the VEGF, p-Akt and p-ERK signaling pathways. These results provide experimental evidence of a novel biological activity of 7α,15-dihydroxydehydroabietic acid (5) as a potential antiangiogenic substance. This study also suggests that compound 5 could potentially be a useful Adjuvant therapeutic substance for Cancer prevention and treatment.

Keywords

7α,15-Dihydroxydehydroabietic acid; Angiogenesis; Pinecones; Pinus koraiensis; VEGF.

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