2. Academic Validation
  3. Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002

Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002

  • J Nat Prod. 2018 Apr 27;81(4):1045-1049. doi: 10.1021/acs.jnatprod.7b00673.
Cai-Juan Zheng 1,  Meng Bai 1,  Xue-Ming Zhou 1,  Guo-Lei Huang 1,  Tai-Ming Shao 2,  You-Ping Luo 1,  Zhi-Gang Niu 1,  Yan-Yan Niu 1,  Guang-Ying Chen 1,  Chang-Ri Han 2
Affiliations

Affiliations

  • 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering , Hainan Normal University , Haikou , Hainan 571158 , People's Republic of China.
  • 2 Hainan Institute of Science and Technology , Haikou 571126 , People's Republic of China.
PMID: 29489361 DOI: 10.1021/acs.jnatprod.7b00673
Abstract

Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and Antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.

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