2. Academic Validation
  3. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

  • Cancer Cell. 2018 Mar 12;33(3):495-511.e12. doi: 10.1016/j.ccell.2018.02.002.
Tamara Maes 1,  Cristina Mascaró 2,  Iñigo Tirapu 2,  Angels Estiarte 2,  Filippo Ciceri 2,  Serena Lunardi 2,  Nathalie Guibourt 2,  Alvaro Perdones 2,  Michele M P Lufino 2,  Tim C P Somervaille 3,  Dan H Wiseman 3,  Cihangir Duy 4,  Ari Melnick 5,  Christophe Willekens 6,  Alberto Ortega 2,  Marc Martinell 2,  Nuria Valls 2,  Guido Kurz 2,  Matthew Fyfe 2,  Julio Cesar Castro-Palomino 2,  Carlos Buesa 2
Affiliations

Affiliations

  • 1 Oryzon Genomics, S.A. Carrer Sant Ferran 74, 08940 Cornellà de Llobregat, Spain. Electronic address: tmaes@oryzon.com.
  • 2 Oryzon Genomics, S.A. Carrer Sant Ferran 74, 08940 Cornellà de Llobregat, Spain.
  • 3 Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • 4 Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, 10065 NY, USA.
  • 5 Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, 10065 NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, 10065 NY, USA.
  • 6 Drug Development Department (DITEP) and Hematology Department, Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.
PMID: 29502954 DOI: 10.1016/j.ccell.2018.02.002
Abstract

The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML. ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of an AML xenograft model, and extends survival in a mouse PDX (patient-derived xenograft) model of T cell acute leukemia. Surrogate pharmacodynamic biomarkers developed based on expression changes in leukemia cell lines were translated to samples from patients treated with ORY-1001. ORY-1001 is a selective KDM1A inhibitor in clinical trials and is currently being evaluated in patients with leukemia and solid tumors.

Keywords

KDM1A; LSD1; ORY-1001; acute myeloid leukemia; differentiation; epigenetic; histone methylation.

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