Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

During the pathogenesis of gastric Cancer, Akt signaling is considered as a pivotal inducer of gastric Cancer development. Here we report the identification of Anticancer activities of deguelin, a natural agent that inhibits Akt signaling. When applied to MGC-803 and MKN-45 cells, deguelin suppressed the proliferation and arrested cell cycle by p21-mediated inhibition of cyclin E. We further present in vitro evidence that deguelin promoted Apoptosis of Cancer cells by decreasing the phospho-Akt signaling and affecting expression of the apoptosis-associated genes Bax and Bcl-2. Additionally, deguelin was found to suppress the migration and invasion of gastric Cancer cells. Taken together, these results indicated that deguelin exerted Anticancer activity of human gastric Cancer MGC-803 and MKN-45 cells in vitro.