2. Academic Validation
  3. Enterococcus faecalis lipoteichoic acid regulates macrophages autophagy via PI3K/Akt/mTOR pathway

Enterococcus faecalis lipoteichoic acid regulates macrophages autophagy via PI3K/Akt/mTOR pathway

  • Biochem Biophys Res Commun. 2018 Apr 15;498(4):1028-1036. doi: 10.1016/j.bbrc.2018.03.109.
Dongjia Lin 1,  Yan Gao 1,  Luodan Zhao 2,  Yanhuo Chen 1,  Shaofeng An 1,  Zhixiang Peng 3
Affiliations

Affiliations

  • 1 Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56 Lingyuan Xi Road, Guangzhou 510055, Guangdong, China; Guangdong Province Key Laboratory of Stomatology, No. 74, 2nd Zhongshan Road, Guangzhou 510080, Guangdong, China.
  • 2 Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangzhou Higher Education Institutes, Sun Yat-Sen University, Guangzhou, Guangdong, China; Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
  • 3 Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56 Lingyuan Xi Road, Guangzhou 510055, Guangdong, China; Guangdong Province Key Laboratory of Stomatology, No. 74, 2nd Zhongshan Road, Guangzhou 510080, Guangdong, China. Electronic address: pengzhix@mail.sysu.edu.cn.
PMID: 29551680 DOI: 10.1016/j.bbrc.2018.03.109
Abstract

Enterococcus faecalis (E. faecalis) Infection is considered an important etiological factor for the development of persistent apical periodontitis (PAP), but the exact mechanisms of Autophagy between E. faecalis and immune cells remain unknown. In this study, we elucidated how E. faecalis lipoteichoic acid (LTA) is associated with macrophages Autophagy. We found that E. faecalis LTA apparently activated macrophage Autophagy with significant increase of autophagosomes and Autophagy relative protein. Meanwhile, we noticed significantly decreasing expression of p-Akt and p-mTOR. However, these effect were absent in macrophages knockdown of Beclin1. In summary, these findings suggested E. faecalis LTA may increased macrophages Autophagy via inhibiting PI3K/Akt/mTOR pathway and this process was Beclin1 dependent.

Keywords

Autophagy; Beclin1; Enterococcus faecalis; Lipoteichoic acid; Macrophages; PI3K/Akt/mTOR.

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