2. Academic Validation
  3. Depleting Macrophages In Vivo with Clodronate-Liposomes

Depleting Macrophages In Vivo with Clodronate-Liposomes

  • Methods Mol Biol. 2018:1784:259-262. doi: 10.1007/978-1-4939-7837-3_23.
Stéphanie G Moreno 1 2 3 4 5
Affiliations

Affiliations

  • 1 CEA/DRF/IBFJ/iRCM/LRTS, Fontenay aux Roses, France. stephanie.moreno@cea.fr.
  • 2 INSERM U967, Fontenay aux Roses, France. stephanie.moreno@cea.fr.
  • 3 Université Paris-Diderot, Paris, France. stephanie.moreno@cea.fr.
  • 4 Université Paris-Sud, Orsay, France. stephanie.moreno@cea.fr.
  • 5 Equipe labellisée Ligue contre le Cancer, Fontenay aux Roses, France. stephanie.moreno@cea.fr.
PMID: 29761405 DOI: 10.1007/978-1-4939-7837-3_23
Abstract

In order to decipher the role of macrophages in vivo, it could be necessary to establish a model of macrophage depletion in the whole animal. One method to obtain animal models efficiently depleted in macrophages in different tissues (bone marrow, spleen, liver, lungs, brain, gut, peritoneal cavity, lymph nodes/vessels) and blood is the use of a clodronate-liposome solution.Here, we describe the protocol used to deplete efficiently macrophages in mouse bone marrow.

Keywords

Bone marrow; Clodronate; Macrophages; Retro-orbital injection.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z