2. Academic Validation
  3. Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

  • J Nat Prod. 2018 Jun 22;81(6):1444-1450. doi: 10.1021/acs.jnatprod.8b00175.
Jaeyoung Kwon 1,  Hyaemin Lee,  Young Hye Seo 2 3,  Jieun Yun 4,  Jun Lee 2 3,  Hak Cheol Kwon 1,  Yuanqiang Guo 5,  Jong Soon Kang 6,  Jae-Jin Kim,  Dongho Lee
Affiliations

Affiliations

  • 1 Natural Constituents Research Center , Korea Institute of Science and Technology (KIST) Gangneung Institute , Gangneung 25451 , Republic of Korea.
  • 2 Herbal Medicine Research Division , Korea Institute of Oriental Medicine , Daejeon 34054 , Republic of Korea.
  • 3 Convergence Research Center for Diagnosis, Treatment and Care System of Dementia , Korea Institute of Science and Technology , Seoul 02792 , Republic of Korea.
  • 4 Department of Pharmaceutical Engineering , Cheongju University , Cheongju 28503 , Republic of Korea.
  • 5 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300353 , People's Republic of China.
  • 6 Laboratory Animal Resource Center , Korea Research Institute of Bioscience and Biotechnology , Cheongju 28116 , Republic of Korea.
PMID: 29878761 DOI: 10.1021/acs.jnatprod.8b00175
Abstract

A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

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