2. Academic Validation
  3. Piperidine alkaloids and xanthone from the roots of Caulophyllum robustum Maxim

Piperidine alkaloids and xanthone from the roots of Caulophyllum robustum Maxim

  • Fitoterapia. 2019 Jan;132:22-25. doi: 10.1016/j.fitote.2018.07.014.
Hui-Xiang Yang 1,  Wei Li 1,  Qian Li 1,  Hong-Lian Ai 1,  Zheng-Hui Li 1,  Rong Huang 1,  Tao Feng 2,  Ji-Kai Liu 3
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
  • 2 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: tfeng@mail.sceuc.edu.cn.
  • 3 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: jkliu@mail.kib.ac.cn.
PMID: 30056184 DOI: 10.1016/j.fitote.2018.07.014
Abstract

Two undescribed piperidine racemates, (±)-caulophines A and B (1 and 2), a new N-containing xanthone derivative (3), together with six known piperidines, were isolated from the roots of Caulophyllum robustum Maxim. Their structures were determined by extensive spectroscopic techniques. Compounds 3 and 7 exhibited weak cytotoxicities against human palace Cancer hela cell line with inhibitory rates of 32.2% and 39.7%, respectively, at the concentration of 40 μM.

Keywords

Caulophyllum robustom; Cytotoxicity; Piperidines; Xanthone.

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