2. Academic Validation
  3. Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata

Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata

  • J Nat Prod. 2018 Sep 28;81(9):2041-2049. doi: 10.1021/acs.jnatprod.8b00362.
Ke Xu 1,  Yun Gao 1,  Yue-Lan Li 1,  Fei Xie 1,  Zun-Tian Zhao 2,  Hong-Xiang Lou 1
Affiliations

Affiliations

  • 1 Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences , Shandong University , No. 44 West Wenhua Road , Jinan 250012 , People's Republic of China.
  • 2 College of Life Sciences , Shandong Normal University , No. 88 East Wenhua Road , Jinan 250014 , People's Republic of China.
PMID: 30137985 DOI: 10.1021/acs.jnatprod.8b00362
Abstract

Eleven new p-terphenyls, floricolins K-U (1-11), together with 13 biosynthetically related known compounds (12-24) were isolated from an endolichenic fungus, Floricola striata. Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction measurements. The newly isolated p-terphenyls inhibited the growth of A2780, MCF-7, and A549 cell lines. Further evaluation for the multidrug resistance (MDR) reversal activity of compound 5 revealed it enhanced the sensitivity of MCF-7/ADR cells toward adriamycin 39-fold at 10 μM through modulating P-glycoprotein-mediated drug exclusion.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z