2. Academic Validation
  3. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era

Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era

  • J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):459-468. doi: 10.1007/s10295-018-2092-7.
Dandan Chen 1 2,  Qunfei Zhao 3,  Wen Liu 4 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence on Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, 200032, Shanghai, China.
  • 2 Huzhou Center of Bio-Synthetic Innovation, 1366 Hongfeng Road, 313000, Huzhou, China.
  • 3 Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, 201203, Shanghai, China.
  • 4 State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence on Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, 200032, Shanghai, China. wliu@sioc.ac.cn.
  • 5 Huzhou Center of Bio-Synthetic Innovation, 1366 Hongfeng Road, 313000, Huzhou, China. wliu@sioc.ac.cn.
PMID: 30484122 DOI: 10.1007/s10295-018-2092-7
Abstract

2,2'-Bipyridine (2,2'-BP) is the unique molecular scaffold of the bioactive Natural Products represented by caerulomycins (CAEs) and collismycins (COLs). CAEs and COLs are highly similar in the chemical structures in which their 2,2'-BP cores typically contain a di- or tri-substituted ring A and an unmodified ring B. Here, we summarize the CAE and COL-type 2,2'-BP Natural Products known or hypothesized to date: (1) isolated using methods traditional for natural product characterization, (2) created by engineering the biosynthetic pathways of CAEs or COLs, and (3) predicted upon bioinformatics-guided genome mining. The identification of these CAE and COL-type 2,2'-BP Natural Products not only demonstrates the development of research techniques and methods in the field of natural product chemistry but also reflects the general interest in the discovery of CAE and COL-type 2,2'-BP Natural Products.

Keywords

2,2′-Bipyridine; Caerulomycin; Collismycin; Natural product discovery; Natural products.

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