2. Academic Validation
  3. Sesquiterpenoids and triterpenoids from Secamone lanceolata blume with inhibitory effects on nitric oxide production

Sesquiterpenoids and triterpenoids from Secamone lanceolata blume with inhibitory effects on nitric oxide production

  • Fitoterapia. 2019 Mar;133:5-11. doi: 10.1016/j.fitote.2018.11.016.
Panpan Yang 1,  Wanfang Zhu 1,  Jian Xu 1,  Wenyuan Liu 2,  Zhenhuan Dong 2,  Takashi Kikuchi 3,  Takeshi Yamada 3,  Ning Xie 4,  Feng Feng 5,  Jie Zhang 6
Affiliations

Affiliations

  • 1 Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
  • 2 Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
  • 3 Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
  • 4 Jiangxi Qingfeng Pharmaceutical Ltd, Ganzhou 341000, China.
  • 5 Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, China; Jiangsu Food and Pharmaceutical Science College, Huaian, Jiangsu 223003, China. Electronic address: fengsunlight@163.com.
  • 6 Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, China. Electronic address: cpunmc_zj@163.com.
PMID: 30496812 DOI: 10.1016/j.fitote.2018.11.016
Abstract

Five previously undescribed sequiterpenoids, including three guaiane sesquiterpenoids secamonol A (2), secamonester (3), secamonether (4), and one elemanolide sequiterpenoid secamonol B (7), and one eudesmane sesquiterpenoid secamonol C (8) along with nine known compounds were isolated from Secamone lanceolata Blume. Their structures and absolute configurations were established by analyzing of NMR, CD, MS spectrum and single-crystal X-ray diffraction, as well as comparing with the literatures. Compounds 1 and 4-8 exhibited potential inhibition activities of NO production with IC50 values in the range of 27.9-57.5 μM with no obvious cytotoxicities even at the high concentration (100 μM). Whereas, compound 3 showed significant cytotoxicity with CC50 value of 5.6 μM against macrophages RAW264.7 Cells.

Keywords

Anti-inflammatory; Cytotoxicity; Secamone lanceolata Blume; Sesquiterpenoids.

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