2. Academic Validation
  3. The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

  • Invest New Drugs. 2019 Oct;37(5):849-864. doi: 10.1007/s10637-018-0704-8.
Malgorzata Kucinska 1,  Helena Mieszczak 2,  Hanna Piotrowska-Kempisty 2,  Mariusz Kaczmarek 3,  Walter Granig 4,  Marek Murias 5,  Thomas Erker 4
Affiliations

Affiliations

  • 1 Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631, Poznan, Poland. kucinska@ump.edu.pl.
  • 2 Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631, Poznan, Poland.
  • 3 Department of Immunology, Poznan University of Medical Sciences, Poznan, Poland.
  • 4 Department of Medicinal Chemistry, University of Vienna, Vienna, Austria.
  • 5 Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631, Poznan, Poland. marek.murias@ump.edu.pl.
PMID: 30498945 DOI: 10.1007/s10637-018-0704-8
Abstract

It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective Anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N'-(1,2-phenylene)bis3,4,5-trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound in an experimental model employing A549 lung adenocarcinoma cells and CCD39Lu non-tumorigenic lung fibroblasts. Since the results suggested oxidative stress as a co-existing mechanism of the cytotoxic effect exerted by 63 T on tested cells, studies involving the analysis of Reactive Oxygen Species (ROS) generation and markers of oxidative stress in cells incubated with 63 T were carried out. It may be concluded that the selective activity of 63 T against Cancer cells shown in our experiments is caused, at least in part, by the response of the tested cells to 63 T mediated oxidative stress in both tested cell lines.

Keywords

Antioxidative enzymes; Lung cancer; Lung fibroblast; Oxidative stress; Reactive oxygen species.

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