2. Academic Validation
  3. Antitumoral activity of quinoxaline derivatives: A systematic review

Antitumoral activity of quinoxaline derivatives: A systematic review

  • Eur J Med Chem. 2019 Feb 1:163:136-147. doi: 10.1016/j.ejmech.2018.11.059.
M Montana 1,  F Mathias 2,  T Terme 2,  P Vanelle 3
Affiliations

Affiliations

  • 1 Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille, France; Assistance Publique-Hôpitaux de Marseille (AP-HM), Oncopharma, Hôpital Nord, Marseille, France.
  • 2 Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille, France.
  • 3 Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille, France; Assistance Publique-Hôpitaux de Marseille (AP-HM), Service Central de la qualité et de l'information pharmaceutiques (SCQIP), Marseille, France. Electronic address: patrice.vanelle@univ-amu.fr.
PMID: 30503938 DOI: 10.1016/j.ejmech.2018.11.059
Abstract

Cancer is a leading cause of death and a major health problem worldwide. While many effective Anticancer agents are available, the majority of drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, recent research hold promise for the development of more efficient and safer Anticancer drugs. Quinoxaline and its derivatives are becoming recognized as a novel class of chemotherapeutic agents with activity against different tumors. The present review compiles and discusses studies concerning the therapeutic potential of the Anticancer activity of quinoxaline derivatives, covering articles published between July 2013 and July 2018.

Keywords

Anticancer; Biological applications; Chemistry; Kinase inhibitors; Quinoxaline; SAR.

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