2. Academic Validation
  3. Jaboticabin and Related Polyphenols from Jaboticaba ( Myrciaria cauliflora) with Anti-inflammatory Activity for Chronic Obstructive Pulmonary Disease

Jaboticabin and Related Polyphenols from Jaboticaba ( Myrciaria cauliflora) with Anti-inflammatory Activity for Chronic Obstructive Pulmonary Disease

  • J Agric Food Chem. 2019 Feb 6;67(5):1513-1520. doi: 10.1021/acs.jafc.8b05814.
Da-Ke Zhao,  Ya-Na Shi 1,  Vanya Petrova 2 3,  Grace G L Yue 4,  Adam Negrin 2 3,  Shi-Biao Wu 3,  Jeanine M D'Armiento 5,  Clara B S Lau 4,  Edward J Kennelly 2 3
Affiliations

Affiliations

  • 1 Institute of Medicinal Plants , Yunnan Academy of Agricultural Sciences , Kunming , Yunnan 650200 , People's Republic of China.
  • 2 Ph.D. Program in Biology, The Graduate Center , The City University of New York , 365 Fifth Avenue , New York City , New York 10016 , United States.
  • 3 Department of Biological Sciences, Lehman College , The City University of New York , 250 Bedford Park Boulevard West , Bronx , New York 10468 , United States.
  • 4 Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants , The Chinese University of Hong Kong , Shatin , New Territories , Hong Kong.
  • 5 Department of Medicine, College of Physicians and Surgeons , Columbia University , 630 West 168th Street , P&S 9-449, New York City , New York 10032 , United States.
PMID: 30675793 DOI: 10.1021/acs.jafc.8b05814
Abstract

Myrciaria cauliflora (jaboticaba) is an edible fruit common in Brazil that has been used for treating respiratory diseases, including chronic tonsillitis and asthma. This study explores the distribution of an anti-inflammatory depside, jaboticabin, in different parts of the jaboticaba plant as well as major Polyphenols from the wood of jaboticaba, some with biological activity similar to jaboticabin. The peel of the fruit was found to be the major source of jaboticabin. This is the first phytochemical study of the wood of M. cauliflora. The antioxidant-activity-guided fractionation strategy successfully identified 3,3'-dimethylellagic acid-4- O-sulfate from jaboticaba wood. This ellagic acid derivative, in a manner similar to jaboticabin, showed antiradical activity and inhibited the production of the chemokine interleukin-8 after treating the human small airway epithelial cells with cigarette smoke extract. The human intestinal Caco-2 cell studies demonstrated the jaboticabin transport in vitro. The Polyphenols, jaboticabin and 3,3'-dimethyellagic acid-4- O-sulfate, from jaboticaba were both found to exhibit anti-inflammatory activities, thus suggesting the potential use of these compounds or even the fruits themselves for chronic obstructive pulmonary disease.

Keywords

COPD; Myrciaria cauliflora; Myrtaceae; depside; jaboticaba; jaboticabin.

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