2. Academic Validation
  3. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus

GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus

  • J Antibiot (Tokyo). 2019 Apr;72(4):237-240. doi: 10.1038/s41429-019-0144-5.
Xin Qi 1,  Xiaoqian Li 1,  Jianyuan Zhao 1,  Ning He 1,  Yihong Li 1,  Tao Zhang 1,  Shanshan Wang 1,  Liyan Yu 2,  Yunying Xie 3
Affiliations

Affiliations

  • 1 CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  • 2 CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. yly@cpcc.ac.cn.
  • 3 CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. xieyy@imb.pumc.edu.cn.
PMID: 30737454 DOI: 10.1038/s41429-019-0144-5
Abstract

Five alkaloid compounds (1-5), including one new compound, GKK1032C (1), and four known compounds, pyrrospirones E (2) and F (3), and GKK1032B (4) and A2 (5) were isolated from the culture of endophytic fungus Penicillium sp. CPCC 400817. The planar structures of all compounds were elucidated by NMR and MS spectra. The relative configuration of new compound GKK1032C (1) was deduced from the vicinal J-values and ROESY spectral data. Compound 1 exhibited potent Antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 1.6 μg ml-1.

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