2. Academic Validation
  3. Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra

Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra

  • J Nat Prod. 2019 May 24;82(5):1312-1318. doi: 10.1021/acs.jnatprod.9b00046.
Edwin Risky Sukandar 1 2,  Sutin Kaennakam 1,  Kitiya Rassamee 3,  Taslim Ersam 2,  Pongpun Siripong 3,  Santi Tip-Pyang 1
Affiliations

Affiliations

  • 1 Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science , Chulalongkorn University , Bangkok 10330 , Thailand.
  • 2 Natural Products and Synthesis Chemistry Research Laboratory, Department of Chemistry, Faculty of Science , Institut Teknologi Sepuluh Nopember , Kampus ITS Sukolilo , Surabaya 60111 , Indonesia.
  • 3 Natural Products Research Section, Research Division , National Cancer Institute , Bangkok 10400 , Thailand.
PMID: 30978023 DOI: 10.1021/acs.jnatprod.9b00046
Abstract

Nine new Xanthones, tetrandraxanthones A-I (1-9), and 22 known Xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human Cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC50 values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC50 values of 4.3-9.0 μM.

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