2. Academic Validation
  3. BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection

BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection

  • Front Immunol. 2019 Mar 29;10:617. doi: 10.3389/fimmu.2019.00617.
Xueping Yu 1 2,  Yijuan Zheng 1,  Richeng Mao 2,  Zhijun Su 1,  Jiming Zhang 2
Affiliations

Affiliations

  • 1 Department of Infectious Diseases, First Hospital of Quanzhou, Fujian Medical University, Quanzhou, China.
  • 2 Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
PMID: 30984188 DOI: 10.3389/fimmu.2019.00617
Abstract

B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV Infection.

Keywords

B and T lymphocyte attenuator; T lymphocyte; hepatitis B virus; herpes virus entry mediator; milestones.

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