2. Academic Validation
  3. Cytotoxic Tigliane Diterpenoids from Croton damayeshu

Cytotoxic Tigliane Diterpenoids from Croton damayeshu

  • J Nat Prod. 2019 Jun 28;82(6):1550-1557. doi: 10.1021/acs.jnatprod.9b00042.
Jiao-Jiao Cui 1 2,  Kai-Long Ji 1,  Hong-Chun Liu 1,  Bin Zhou 1,  Qun-Fang Liu 1,  Cheng-Hui Xu 1,  Jian Ding 1,  Jin-Xin Zhao 1,  Jian-Min Yue 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • 2 University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , People's Republic of China.
PMID: 31117522 DOI: 10.1021/acs.jnatprod.9b00042
Abstract

Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane Diterpenoids, crodamoids A-J (1-10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against two human tumor cell lines, A549 and HL-60 (IC50: 0.9-2.4 μM).

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