2. Academic Validation
  3. 17- nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei

17- nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei

  • J Nat Prod. 2019 Jun 28;82(6):1565-1575. doi: 10.1021/acs.jnatprod.9b00059.
Zhan-Peng Ge 1 2,  Hong-Chun Liu 1,  Guo-Cai Wang 1,  Qun-Fang Liu 1,  Cheng-Hui Xu 1,  Jian Ding 1,  Yao-Yue Fan 1,  Jian-Min Yue 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • 2 University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , People's Republic of China.
PMID: 31184894 DOI: 10.1021/acs.jnatprod.9b00059
Abstract

Seventeen new 17- nor-cephalotane-type Diterpenoids, fortalpinoids A-Q (1-17), were isolated from the seeds of Cephalotaxus fortunei var. alpine. Compound 12 represents the first 17- nor-cephalotane-type diterpenoid featuring an 8-oxabicyclo[3.2.1]oct-2-ene moiety. The absolute configuration of fortunolide A (18) was determined for the first time, and the structure of cephinoid Q was revised to 14- epi-cephafortoid A (24) by X-ray crystallographic data analysis. Some of the compounds showed significant cytotoxicity against A549 and HL-60 cells, and the structure-activity relationship of this compound class is discussed.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z