2. Academic Validation
  3. AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes

AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes

  • Metallomics. 2019 Jul 17;11(7):1200-1206. doi: 10.1039/c9mt00103d.
Hui Huang 1,  Mengxue Zhou 1,  Lifo Ruan 1,  Dongqing Wang 2,  Huiru Lu 2,  Jiayu Zhang 2,  Jun Chen 1,  Yi Hu 1,  Zhifang Chai 1
Affiliations

Affiliations

  • 1 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multidisciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China. huyi@ihep.ac.cn chenjun@ihep.ac.cn and University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 2 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multidisciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China. huyi@ihep.ac.cn chenjun@ihep.ac.cn.
PMID: 31241124 DOI: 10.1039/c9mt00103d
Abstract

Environmental factors may play a critical role in the etiology and pathogenesis of Parkinson's disease (PD). However, the association of PD with specific chemical species remains largely unknown. Here we prepared three kinds of iron oxide nanoparticles and examined their cytotoxicity in a cellular model of PD. We found that lysosome-targeted nanoparticles showed significant cytotoxicity in SH-SY5Y cells. Inhibition of AMPK could aggravate the neurotoxicity of lysosome-targeted nanoparticles as well as mitochondrion-targeted nanoparticles. Alteration of mitochondrial membrane potentials was found to be in agreement with the neurotoxicity of iron nanoparticles. These results suggested an important role of AMPK in regulating iron nanoparticle-associated neurotoxicity.

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