2. Academic Validation
  3. Prenylated Bibenzyls from the Chinese Liverwort Radula constricta and Their Mitochondria-Derived Paraptotic Cytotoxic Activities

Prenylated Bibenzyls from the Chinese Liverwort Radula constricta and Their Mitochondria-Derived Paraptotic Cytotoxic Activities

  • J Nat Prod. 2019 Jul 26;82(7):1741-1751. doi: 10.1021/acs.jnatprod.8b00897.
Chun-Yang Zhang 1,  Yun Gao 1,  Rong-Xiu Zhu 2,  Ya-Nan Qiao 1,  Jin-Chuan Zhou 3,  Jiao-Zhen Zhang 1,  Yi Li 1,  Si-Wen Li 1,  Sheng-Hua Fan 1,  Hong-Xiang Lou 1
Affiliations

Affiliations

  • 1 Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education , Shandong University , Jinan 250012 , People's Republic of China.
  • 2 School of Chemistry and Chemical Engineering , Shandong University , Jinan 250010 , People's Republic of China.
  • 3 School of Pharmacy , Linyi University , Linyi 276000 , People's Republic of China.
PMID: 31268321 DOI: 10.1021/acs.jnatprod.8b00897
Abstract

Nine new prenylated bibenzyls, radstrictins A-I (1-9), and 11 known congeners were obtained from the Chinese liverwort Radula constricta. Their structures were identified by analysis of HRMS, NMR, and electronic circular dichroism data. Radstrictins A-F (1-6) were isolated as a racemate or scalemic mixtures. All the isolated compounds were subjected to cytotoxicity assessment. Methyl 2,4-dihydroxy-3-(3-methyl-2-butenyl)-6-phenethylbenzoate (10) exhibited significant activity against human lung Cancer cell lines A549 and NCI-H1299 with IC50 values of 6.0 and 5.1 μM, respectively. Further research revealed that cell death triggered by 10 occurred via mitochondria-derived Paraptosis.

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