1. Academic Validation
  2. Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases

Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases

  • J Med Chem. 2019 Jul 25;62(14):6512-6524. doi: 10.1021/acs.jmedchem.9b00089.
Christine Yueh Justin Rettenmaier 1 Bing Xia David R Hall 2 Andrey Alekseenko Kathryn A Porter Krister Barkovich 1 Gyorgy Keseru 3 Adrian Whitty James A Wells 1 Sandor Vajda Dima Kozakov
Affiliations

Affiliations

  • 1 Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology , University of California , 1700 Fourth Street , San Francisco , California 9415 , United States.
  • 2 Acpharis Incorporated , Holliston , Massachusetts 01746 , United States.
  • 3 Medicinal Chemistry Research Group , Research Center for Natural Sciences , Magyar tudósok krt. 2 , H-1117 Budapest , Hungary.
Abstract

The inhibition of kinases has been pursued by the pharmaceutical industry for over 20 years. While the locations of the sites that bind type II and III inhibitors at or near the adenosine 5'-triphosphate binding sites are well defined, the literature describes 10 different regions that were reported as regulatory hot spots in some kinases and thus are potential target sites for type IV inhibitors. Kinase Atlas is a systematic collection of binding hot spots located at the above ten sites in 4910 structures of 376 distinct kinases available in the Protein Data Bank. The hot spots are identified by FTMap, a computational analogue of experimental fragment screening. Users of Kinase Atlas ( https://kinase-atlas.bu.edu ) may view summarized results for all structures of a particular kinase, such as which binding sites are present and how druggable they are, or they may view hot spot information for a particular kinase structure of interest.

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