2. Academic Validation
  3. Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer

Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer

  • Cells. 2019 Jul 22;8(7):761. doi: 10.3390/cells8070761.
Saori Yoshida 1,  Hotaka Kawai 2,  Takanori Eguchi 3 4,  Shintaro Sukegawa 1 5,  May Wathone Oo 1,  Chang Anqi 1 6,  Kiyofumi Takabatake 1,  Keisuke Nakano 1 7,  Kuniaki Okamoto 8,  Hitoshi Nagatsuka 1 7
Affiliations

Affiliations

  • 1 Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
  • 2 Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. hotaka-k@okayama-u.ac.jp.
  • 3 Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. eguchi@okayama-u.ac.jp.
  • 4 Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. eguchi@okayama-u.ac.jp.
  • 5 Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa 760-8557, Japan.
  • 6 Department of Anatomy, Basic Medicine Science College, Harbin Medical University, Harbin 150076, China.
  • 7 Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
  • 8 Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
PMID: 31336612 DOI: 10.3390/cells8070761
Abstract

CXCR4 is a Chemokine Receptor crucial in tumor progression, although the angiogenic role of CXCR4 in oral squamous cell carcinoma (OSCC) has not been investigated. Here we show that CXCR4 is crucial for tumor angiogenesis, thereby supporting tumor survival in OSCC. Immunohistochemistry on human clinical specimens revealed that CXCR4 and a tumor vasculature marker CD34 were co-distributed in tumor vessels in human OSCC specimens. To uncover the effects of CXCR4 inhibition, we treated the OSCC-xenografted mice with AMD3100, so-called plerixafor, an antagonist of CXCR4. Notably, we found a unique pathophysiological structure defined as tumor angiogenic inhibition triggered necrosis (TAITN), which was induced by the CXCR4 antagonism. Treatment with AMD3100 increased necrotic areas with the induction of hypoxia-inducible factor-1α in the xenografted tumors, suggesting that AMD3100-induced TAITN was involved in hypoxia and ischemia. Taken together, we demonstrated that CXCR4 plays a crucial role in tumor angiogenesis required for OSCC progression, whereas TAITN induced by CXCR4 antagonism could be an effective anti-angiogenic therapeutic strategy in OSCC treatment.

Keywords

CXCR4 antagonist; hypoxia; oral squamous cell carcinoma; tumor angiogenic inhibition triggered necrosis (TAITN); tumor blood vessel.

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