2. Academic Validation
  3. Pyrimidine Nucleosides from Streptomyces sp. SSA28

Pyrimidine Nucleosides from Streptomyces sp. SSA28

  • J Nat Prod. 2019 Sep 27;82(9):2509-2516. doi: 10.1021/acs.jnatprod.9b00260.
Cheng-Dong Xu 1,  Hao-Jian Zhang 1,  Zhong-Jun Ma 1
Affiliations

Affiliation

  • 1 Institute of Marine Biology and Pharmacology, Ocean College , Zhejiang University , Zhoushan 316021 , People's Republic of China.
PMID: 31436991 DOI: 10.1021/acs.jnatprod.9b00260
Abstract

Eleven new pyrimidine nucleosides (1-11) and 12 known analogues (12-23) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new structures were elucidated by extensive NMR spectroscopic analysis and HRESIMS data. The absolute configurations of compound 1 were determined by X-ray diffraction. The configurations of 2-16 were investigated by ECD calculations. Compounds 11-16 showed cytotoxicity against HCT-116 human colon Cancer cell lines with IC50 values from 0.39 ± 0.03 to 6.63 ± 0.47 μM.

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