2. Academic Validation
  3. Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

  • Biomolecules. 2019 Nov 14;9(11):738. doi: 10.3390/biom9110738.
Bahare Salehi 1,  Shashi Upadhyay 2,  Ilkay Erdogan Orhan 3,  Arun Kumar Jugran 4,  Sumali L D Jayaweera 5,  Daniel A Dias 5,  Farukh Sharopov 6,  Yasaman Taheri 7,  Natália Martins 8 9,  Navid Baghalpour 7,  William C Cho 10,  Javad Sharifi-Rad 11
Affiliations

Affiliations

  • 1 Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran.
  • 2 G. B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi- Katarmal, Almora-263643, Uttarakhand, India.
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
  • 4 G. B. Pant National Institute of Himalayan Environment and Sustainable Development, Garhwal Regional Centre, Srinagar-246174, Uttarakhand, India.
  • 5 School of Health and Biomedical Sciences, Discipline of Laboratory Medicine, RMIT University, Bundoora PO Box 71, VIC 3083, Australia.
  • 6 Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan.
  • 7 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran.
  • 8 Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
  • 9 Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.
  • 10 Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China.
  • 11 Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran.
PMID: 31739596 DOI: 10.3390/biom9110738
Abstract

α- and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants' essential oils. A wide range of pharmacological activities have been reported, including Antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α- and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.

Keywords

bioavailability; clinical studies; cytotoxicity; pharmacological activities; α-pinene, β-pinene.

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