2. Academic Validation
  3. Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression

Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression

  • Bioorg Med Chem. 2020 Jan 15;28(2):115233. doi: 10.1016/j.bmc.2019.115233.
Yuki Hitora 1,  Kentaro Takada 2,  Yuji Ise 3,  Sau Pinn Woo 4,  Seiya Inoue 5,  Naoki Mori 5,  Hirosato Takikawa 5,  Shohei Nakamukai 1,  Shigeru Okada 1,  Shigeki Matsunaga 6
Affiliations

Affiliations

  • 1 Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
  • 2 Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address: ktakada@kitasato-u.ac.jp.
  • 3 Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Sugashima-cho, Toba-shi, Mie 517-0004, Japan.
  • 4 Center for Marine and Coastal Studies, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.
  • 5 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bukyo-ku, Tokyo 113-8657, Japan.
  • 6 Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address: assmats@mail.ecc.-tokyo.ac.jp.
PMID: 31848114 DOI: 10.1016/j.bmc.2019.115233
Abstract

New sesquiterpene Quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.

Keywords

Cell-cycle; Marine sponge; Structure elucidation; Terpenoid.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z