2. Academic Validation
  3. C-Type Lectin Receptors in Phagocytosis

C-Type Lectin Receptors in Phagocytosis

  • Curr Top Microbiol Immunol. 2020;429:1-18. doi: 10.1007/82_2020_198.
Kai Li 1 2,  David M Underhill 3 4
Affiliations

Affiliations

  • 1 F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
  • 2 Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
  • 3 F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. David.Underhill@csmc.edu.
  • 4 Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. David.Underhill@csmc.edu.
PMID: 32060644 DOI: 10.1007/82_2020_198
Abstract

C-type Lectin Receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a second protein, often the Fc receptor common gamma chain (FcRγ), that mediates signaling. Many CLRs directly recognize microbial cell walls and influence innate immunity by activating inflammatory and antimicrobial responses in phagocytes. In this review, we examine the contributions of certain CLRs to activation and regulation of phagocytosis in cells such as macrophages, dendritic cells and neutrophils.

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