2. Academic Validation
  3. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

  • Curr Top Med Chem. 2020;20(10):815-834. doi: 10.2174/1568026620666200303123102.
Dima A Sabbah 1,  Rima Hajjo 1,  Kamal Sweidan 2
Affiliations

Affiliations

  • 1 Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Jordan.
  • 2 Department of Chemistry, The University of Jordan, Amman 11942, Jordan.
PMID: 32124699 DOI: 10.2174/1568026620666200303123102
Abstract

The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and Cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.

Keywords

EGF; EGFR; ERBB-1; HER-1; Inhibitors; TGF-α; Tyrosine kinase; cancer; mAbs..

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