2. Academic Validation
  3. Salvianolic acid B improved insulin resistance through suppression of hepatic ER stress in ob/ob mice

Salvianolic acid B improved insulin resistance through suppression of hepatic ER stress in ob/ob mice

  • Biochem Biophys Res Commun. 2020 Jun 4;526(3):733-737. doi: 10.1016/j.bbrc.2020.03.124.
Yanan Shi 1,  Da Pan 1,  Lihui Yan 1,  Hengyu Chen 1,  Ximei Zhang 2,  Jihong Yuan 3,  Biao Mu 4
Affiliations

Affiliations

  • 1 NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, 300134, China.
  • 2 Department of Radiation Oncology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin, 300060, China.
  • 3 NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, 300134, China. Electronic address: yuanjihong166@163.com.
  • 4 NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, 300134, China. Electronic address: xzhen88@163.com.
PMID: 32265029 DOI: 10.1016/j.bbrc.2020.03.124
Abstract

Impaired Insulin sensitivity of insulin-sensitive tissues plays a major role in the pathogenesis of type 2 diabetes, salvianolic acid B (SalB), a natural antioxidant usually treated various cardiovascular diseases was also reported potential utility on diabetes and dyslipidemia. Based on these, we aimed to explored whether the antioxidant effect of SalB play a pivotal role in the molecular mechanisms leading to Insulin resistance. We found that SalB improved glucose tolerance and Insulin sensitivity, decreased serum ALT, AST and ALP levels of ob/ob mice. Also, transcription of Bip and CHOP, phosphorylation of PERK and IRE1 for endoplasmic reticulum stress (ER) and phosphorylation of IRS-1 for Insulin sensitivity in the liver of ob/ob mice were relieved by SalB. Further, SalB decreased phosphorylation of PERK, IRE1 and IRS1 and transcription of Bip and CHOP stimulated by palmitate of hepatic cells HL7702, but did not reversed phosphorylation of JNK and IRS1 and transcription of Bip and CHOP when ER stress was stimulated by tunicamycin. These data shows that SalB improved Insulin resistance of ob/ob mice through suppression of hepatic ER stress.

Keywords

ER stress; Insulin resistance; Ob/ob mice; Salvianolic acid B.

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