2. Academic Validation
  3. Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest

Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest

  • Nat Prod Bioprospect. 2020 Jun;10(3):131-140. doi: 10.1007/s13659-020-00240-6.
Rong-Fang Mu 1 2,  Yan-Fen Niu 3,  Qian Wang 1 2,  Hui-Min Zhou 1 2,  Jing Hu 1,  Wan-Ying Qin 1 2,  Wen-Yong Xiong 4 5 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
  • 2 University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • 3 Biomedical Engineering Research Center, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
  • 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China. xiong.wenyong@mail.kib.ac.cn.
  • 5 Key Laboratory of Medicinal Chemistry for Natural Resource, Yunnan University, Kunming, 650500, Yunnan, People's Republic of China. xiong.wenyong@mail.kib.ac.cn.
  • 6 University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. xiong.wenyong@mail.kib.ac.cn.
PMID: 32314168 DOI: 10.1007/s13659-020-00240-6
Abstract

Eriocalyxin B, an ent-Kaurene diterpenoid extracted from a traditional Chinese herb Isodon eriocalyx, has been shown to possess multifunctional activities such as anti-cancer and anti-inflammatory. However, the function and mechanism of the compound in adipocyte differentiation is still unknown. Here we reported that eriocalyxin B blunted adipogenesis remarkably by inhibiting the accumulation of lipid droplets, triglycerides and the expressions of adipogenesis-related factors, including C/EBPβ, C/EBPα, PPARγ, and FABP4. Moreover, we showed that the inhibition might be the consequence of cell cycle being arrested at the G2/M phase during the mitotic clonal expansion of adipocyte differentiation, most likely by suppressing mRNAs and proteins of CDK1, CDK2, Cyclin A and Cyclin B1. Overall, we conclude that eriocalyxin B is capable of inhibiting adipocyte differentiation at the early stage through downregulating the proteins involved in cell cycle progression.

Keywords

Adipocyte differentiation; Cell cycle; Eriocalyxin B.

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