2. Academic Validation
  3. Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian

Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian

  • Curr Biol. 2020 Jun 8;30(11):R633-R634. doi: 10.1016/j.cub.2020.04.032.
Erika M Ellis 1,  Rikard Frederiksen 1,  Ala Morshedian 1,  Gordon L Fain 2,  Alapakkam P Sampath 3
Affiliations

Affiliations

  • 1 Department of Ophthalmology and Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • 2 Department of Ophthalmology and Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: gfain@ucla.edu.
  • 3 Department of Ophthalmology and Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: asampath@jsei.ucla.edu.
PMID: 32516608 DOI: 10.1016/j.cub.2020.04.032
Abstract

Ellis et al. show that retinal ON and OFF bipolar cells, and the novel Metabotropic Glutamate Receptors of ON bipolar-cell dendrites, are both present in lamprey. They conclude that the fundamental organizing principle of separate ON and OFF pathways first appeared in the vertebrate visual system over 500 million years ago in the late Cambrian.

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