2. Academic Validation
  3. PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition

PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition

  • J Cell Mol Med. 2020 Jul;24(14):8221-8235. doi: 10.1111/jcmm.15491.
Pengzhen Dong 1,  Hao Fu 2,  Lin Chen 3,  Shihui Zhang 4,  Xin Zhang 4,  Huimin Li 1 3,  Dongdong Wu 5,  Xinying Ji 1 6
Affiliations

Affiliations

  • 1 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, China.
  • 2 Huaihe Hospital, Henan University, Kaifeng, China.
  • 3 Department of Histology and Embryology, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, School of Basic Medical Sciences, Henan University, Kaifeng, China.
  • 4 Institute for Innovative Drug Design and Evaluation, School of Pharmacy, Henan University, Kaifeng, China.
  • 5 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Stomatology, Henan University, Kaifeng, China.
  • 6 Kaifeng Key Laboratory of Infection and Biological Safety, Henan University College of Medicine, Henan University, Kaifeng, China.
PMID: 32548978 DOI: 10.1111/jcmm.15491
Abstract

Ever reports showed that PCNP is associated with human cancers including neuroblastoma and lung Cancer. However, the role and underlying molecular mechanism of PCNP in ovarian Cancer have not been plenty elucidated. Herein, we first investigated the expression of PCNP in ovarian Cancer tissues and cells, the effects of PCNP in ovarian Cancer proliferation, Apoptosis, migration and invasion, and determined the molecular mechanism of PCNP in ovarian Cancer progression. The results indicated that PCNP was significantly overexpressed in human ovarian Cancer tissues and cells, and related to poor prognosis in ovarian Cancer patients. In addition, we also detected that PCNP promoted ovarian Cancer cells growth, migration and invasion, as well as inhibited ovarian Cancer cells Apoptosis. Mechanistically, PCNP binding to β-catenin promoted β-catenin nuclear translocation and further activated Wnt/β-catenin signalling pathway. Moreover, PCNP regulated the expression of genes involved in EMT and further triggered EMT occurrence. Conclusionally, PCNP may promote ovarian Cancer progression through activating Wnt/β-catenin signalling pathway and EMT, acting as a novel and promising target for treating ovarian Cancer.

Keywords

PEST-containing nuclear protein; Wnt; epithelial-mesenchymal transition; migration; ovarian cancer; β-catenin.

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