2. Academic Validation
  3. An overview on the biosynthesis and metabolic regulation of monacolin K/lovastatin

An overview on the biosynthesis and metabolic regulation of monacolin K/lovastatin

  • Food Funct. 2020 Jul 22;11(7):5738-5748. doi: 10.1039/d0fo00691b.
Yaru Zhang 1,  Zhiting Chen 1,  Qinyou Wen 1,  Zixiao Xiong 1,  Xiaohua Cao 2,  Zhenghuai Zheng 3,  Yangxin Zhang 3,  Zhiwei Huang 4
Affiliations

Affiliations

  • 1 College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China. hzwfau@163.com and Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • 2 Key Laboratory of Crop Biotechnology (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou 350002, China.
  • 3 College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China. hzwfau@163.com.
  • 4 College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China. hzwfau@163.com and Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China and China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
PMID: 32555902 DOI: 10.1039/d0fo00691b
Abstract

Lovastatin/monacolin K (MK) is used as a lipid lowering drug, due to its effective hypercholesterolemic properties, comparable to synthetic statins. Lovastatin's biosynthetic pathway and gene cluster composition have been studied in depth in Aspergillus terreus. Evidence shows that the MK biosynthetic pathway and gene cluster in Monascus sp. are similar to those of lovastatin in A. terreus. Currently, research efforts have been focusing on the metabolic regulation of MK/lovastatin synthesis, and the evidence shows that a combination of extracellular and intracellular factors is essential for proper MK/lovastatin metabolism. Here, we comprehensively review the research progress on MK/lovastatin biosynthetic pathways, its synthetic precursors and inducing substances and metabolic regulation, with a view to providing reference for future research on Fungal metabolism regulation and metabolic engineering for MK/lovastatin production.

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