2. Academic Validation
  3. Pim1 kinase provides protection against high glucose-induced stress and apoptosis in cultured dorsal root ganglion neurons

Pim1 kinase provides protection against high glucose-induced stress and apoptosis in cultured dorsal root ganglion neurons

  • Neurosci Res. 2021 Aug;169:9-16. doi: 10.1016/j.neures.2020.06.004.
Yuantong Liu 1,  Yue Shang 2,  Zihan Yan 2,  Hao Li 3,  Zhen Wang 2,  Zhenzhong Li 2,  Zhen Liu 4
Affiliations

Affiliations

  • 1 Department of Anatomy, Shandong University School of Basic Medical Sciences, Jinan, 250012, China; Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, 518020, China.
  • 2 Department of Anatomy, Shandong University School of Basic Medical Sciences, Jinan, 250012, China.
  • 3 Department of Orthopaedics, Shandong University Qilu Hospital, Jinan, 250012, China.
  • 4 Department of Anatomy, Shandong University School of Basic Medical Sciences, Jinan, 250012, China. Electronic address: zhen@sdu.edu.cn.
PMID: 32593591 DOI: 10.1016/j.neures.2020.06.004
Abstract

The pathogenesis of diabetic peripheral neuropathy (DPN) is complex and not well understood. Recently, oxidative stress and endoplasmic reticulum (ER) stress induced by hyperglycemia have been demonstrated to play a critical role in neuronal Apoptosis, which then contributing to DPN. However, the specific molecular mechanism that underlies the hyperglycemia-induced neuronal stresses and Apoptosis remains largely unknown. In this study, we demonstrated for the first time that PIM1 kinase is a positive modulator of dorsal root ganglion (DRG) neuron survival in vitro. Hyperglycemia causes compensatory upregulation of PIM1 kinase in the DRG neurons, which provides protection against high glucose-induced oxidative stress and ER stress. Pharmacological inhibition of PIM1 not only sensitizes the stress response to high glucose in the DRG neurons, but also accelerates the Apoptosis of DRG neurons in vitro. Therefore, our work provides experimental evidence for the prevention of high glucose-induced neuronal stress and Apoptosis by targeting PIM1 kinase.

Keywords

Apoptosis; Diabetic peripheral neuropathy; Dorsal root ganglion; Endoplasmic reticulum stress; Oxidative stress; Pim1 kinase.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-18086
    98.01%, Pim-1 抑制剂
    Pim
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