2. Academic Validation
  3. TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes

TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes

  • FEBS Lett. 2020 Sep;594(17):2923-2930. doi: 10.1002/1873-3468.13900.
Min-Jung Park 1,  Jiling Liao 2 3 4,  Dong-Il Kim 1 4
Affiliations

Affiliations

  • 1 Department of Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
  • 2 Gerontology Department, Beijing Hospital, National Center of Gerontology, Beijing, China.
  • 3 Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • 4 Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
PMID: 32767856 DOI: 10.1002/1873-3468.13900
Abstract

We previously reported the involvement of protein arginine methyltransferase 1 (PRMT1) in adipocyte thermogenesis. Here, we investigate the effects of PRMT1 inhibitors on thermogenesis. Unexpectedly, we find that the PRMT1 Inhibitor TC-E 5003 (TC-E) induces the thermogenic properties of primary murine and human subcutaneous adipocytes. TC-E treatment upregulates the expression of Ucp1 and FGF21 significantly and activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. We further find that the thermogenic effects of TC-E are independent of PRMT1 and beta-adrenergic receptors. Our data indicate that TC-E exerts strong effects on murine and human subcutaneous adipocytes by activating beige adipocytes via PKA signaling.

Keywords

PKA; PRMT1; UCP1; lipolysis; thermogenesis.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z