2. Academic Validation
  3. Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway

Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway

  • Biomed Pharmacother. 2020 Sep;129:110471. doi: 10.1016/j.biopha.2020.110471.
Linjie Ju 1,  Peipei Hu 2,  Ping Chen 3,  Xue Xue 4,  Zhuoqun Li 5,  Feiyan He 6,  Zhixia Qiu 7,  Jun Cheng 8,  Fang Huang 9
Affiliations

Affiliations

  • 1 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China. Electronic address: linjieju1109@163.com.
  • 2 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China. Electronic address: 1810839740@qq.com.
  • 3 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China. Electronic address: 2550198420@qq.com.
  • 4 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China; Nanjing Zhongshan Pharmaceutical Co, Ltd., 21 Hengfa Road, Nanjing Economic and Technological Development Zone, Nanjing, China. Electronic address: 280994476@qq.com.
  • 5 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China; Nanjing Zhongshan Pharmaceutical Co, Ltd., 21 Hengfa Road, Nanjing Economic and Technological Development Zone, Nanjing, China. Electronic address: 529464470@qq.com.
  • 6 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China. Electronic address: hfyfaye@126.com.
  • 7 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China. Electronic address: qiuzhixia_cpu@163.com.
  • 8 Nanjing Zhongshan Pharmaceutical Co, Ltd., 21 Hengfa Road, Nanjing Economic and Technological Development Zone, Nanjing, China. Electronic address: huangfangcpuzyxy@163.com.
  • 9 Department of Chinese Pharmacology and Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, China. Electronic address: huangfang@cpu.edu.cn.
PMID: 32768958 DOI: 10.1016/j.biopha.2020.110471
Abstract

Huoxuezhitong capsule (HXZT, activating blood circulation and relieving pain capsule), has been applied for osteoarthritis since 1974. It consists of Angelica sinensis (Oliv.) Diels, Panax notoginseng (Burkill) F. H. Chen ex C. H., Boswellia sacra, Borneol, Eupolyphaga sinensis Walker, Pyritum. However, the direct effects of HXZT on osteoarthritis and the underlying mechanisms were poorly understood. In this study, we aimed to explore the analgesia effect of HXZT on MIA-induced osteoarthritis rat and the underlying mechanisms. The analgesia and anti-inflammatory effect of HXZT on osteoarthritis in vivo were tested by the arthritis model rats induced by monosodium iodoacetate (MIA).. Mechanistic studies confirmed that HXZT could inhibit the activation of NF-κB and down-regulate the mRNA expression of related inflammatory factors in LPS-induced RAW264.7 and ATDC5 cells. Furtherly, in LPS-induced RAW264.7 cells, HXZT could suppress NF-κB via inhibiting PI3K/Akt pathway. Taken together, HXZT capsule could ameliorate MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway.

Keywords

Analgesia; Anti-inflammation; Ginsenoside Rg1 (CID: 441923); Huoxuezhitong capsule; Lipopolysaccharide (LPS) (CID: 11970143); Notoginsenoside R1 (CID: 441934); Osteoarthritis; PI3K/Akt/ NF-κB pathway; Sodium iodoacetate (MIA) (CID: 5239).

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