2. Academic Validation
  3. Monacycliones G-K and ent-Gephyromycin A, Angucycline Derivatives from the Marine-Derived Streptomyces sp. HDN15129

Monacycliones G-K and ent-Gephyromycin A, Angucycline Derivatives from the Marine-Derived Streptomyces sp. HDN15129

  • J Nat Prod. 2020 Sep 25;83(9):2749-2755. doi: 10.1021/acs.jnatprod.0c00684.
Yimin Chang 1,  Li Xing 1,  Chunxiao Sun 1,  Shuang Liang 2,  Tao Liu 2,  Xiaomin Zhang 1,  Tianjiao Zhu 1,  Blaine A Pfeifer 3,  Qian Che 1,  Guojian Zhang 1 4,  Dehai Li 1 4
Affiliations

Affiliations

  • 1 School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • 2 Department of Pharmacy, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong, People's Republic of China.
  • 3 Department of Chemical and Biological Engineering, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
  • 4 Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, People's Republic of China.
PMID: 32840364 DOI: 10.1021/acs.jnatprod.0c00684
Abstract

Six new angucycline derivatives, named monacycliones G-K (1-5) and ent-gephyromycin A (6), as well as three known ones (7-9) were discovered from the marine sediment-derived actinomycete Streptomyces sp. HDN15129 guided by Global Natural Products Social (GNPS) molecular networking. Structures including absolute configurations were elucidated by extensive NMR, MS, and ECD analyses. Among them, monacyclione G (1) possesses a unique scaffold featuring a xanthone core linked to the aminodeoxysugar ossamine, and monacycliones H-J (2-4) are rare examples of natural angucyclines with an S-methyl group. Monacycliones I and J (3 and 4) showed cytotoxic activity against multiple human Cancer cell lines, with IC50 values ranging from 3.5 to 10 μM.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z