2. Academic Validation
  3. Pectin: A Long-Neglected Broad-Spectrum Antibacterial

Pectin: A Long-Neglected Broad-Spectrum Antibacterial

  • ChemMedChem. 2020 Dec 3;15(23):2228-2235. doi: 10.1002/cmdc.202000518.
Rosaria Ciriminna 1,  Alexandra Fidalgo 2,  Francesco Meneguzzo 3,  Alessandro Presentato 4,  Antonino Scurria 1,  Domenico Nuzzo 5,  Rosa Alduina 4,  Laura M Ilharco 2,  Mario Pagliaro 1
Affiliations

Affiliations

  • 1 Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy.
  • 2 Centro de Química-Física Molecular and IN-Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, Lisboa, 1049-001, Portugal.
  • 3 Istituto per la Bioeconomia, via Madonna del Piano 10, Sesto Fiorentino, 50019, Italy.
  • 4 Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90028, Palermo, Italy.
  • 5 Istituto per la Ricerca e l'Innovazione Biomedica, CNR, via U. La Malfa 153, 90146, Palermo, Italy.
PMID: 32857470 DOI: 10.1002/cmdc.202000518
Abstract

First reported in the late 1930s and partly explained in 1970, the Antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin Polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in Plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering.

Keywords

antibacterial agents, antimicrobial agents; citrus pectin; pectin; polysaccharides.

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