2. Academic Validation
  3. Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials

Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials

  • Signal Transduct Target Ther. 2020 Sep 23;5(1):213. doi: 10.1038/s41392-020-00315-3.
Haiying Lu # 1,  Qiaodan Zhou # 2,  Jun He # 3,  Zhongliang Jiang 4,  Cheng Peng 5,  Rongsheng Tong 6,  Jianyou Shi 7
Affiliations

Affiliations

  • 1 Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 610072, Chengdu, China.
  • 2 Department of Ultrasonic, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, 610072, Chengdu, China.
  • 3 Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, 610041, Sichuan, China.
  • 4 Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
  • 5 The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, 611137, Chengdu, China. pengchengchengdu@126.com.
  • 6 Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 610072, Chengdu, China. tongrs@126.com.
  • 7 Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 610072, Chengdu, China. shijianyoude@126.com.
  • # Contributed equally.
PMID: 32968059 DOI: 10.1038/s41392-020-00315-3
Abstract

Protein-protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including Cancer, infectious diseases, and neurodegenerative diseases. Therefore, targeting PPIs is a direction in treating diseases and an essential strategy for the development of new drugs. In the past few decades, the modulation of PPIs has been recognized as one of the most challenging drug discovery tasks. In recent years, some PPIs modulators have entered clinical studies, some of which been approved for marketing, indicating that the modulators targeting PPIs have broad prospects. Here, we summarize the recent advances in PPIs modulators, including small molecules, Peptides, and Antibodies, hoping to provide some guidance to the design of novel drugs targeting PPIs in the future.

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