2. Academic Validation
  3. Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway

Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway

  • Sci Rep. 2020 Oct 22;10(1):18119. doi: 10.1038/s41598-020-75140-3.
Heon-Su Kim 1,  Jung-Soo Suh 1,  Yoon-Kwan Jang 1,  Sang-Hyun Ahn 1,  Ganesan Raja 2,  Jin-Chul Kim 3,  Youngmi Jung 1 2 4,  Sang Hoon Jung 5,  Tae-Jin Kim 6 7 8
Affiliations

Affiliations

  • 1 Department of Integrated Biological Science, Pusan National University, Pusan, 46241, Republic of Korea.
  • 2 Department of Biological Sciences, Pusan National University, Pusan, 46241, Republic of Korea.
  • 3 Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung, 25451, Republic of Korea.
  • 4 Institute of Systems Biology, Pusan National University, Pusan, 46241, Republic of Korea.
  • 5 Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung, 25451, Republic of Korea. shjung@kist.re.kr.
  • 6 Department of Integrated Biological Science, Pusan National University, Pusan, 46241, Republic of Korea. tjkim77@pusan.ac.kr.
  • 7 Department of Biological Sciences, Pusan National University, Pusan, 46241, Republic of Korea. tjkim77@pusan.ac.kr.
  • 8 Institute of Systems Biology, Pusan National University, Pusan, 46241, Republic of Korea. tjkim77@pusan.ac.kr.
PMID: 33093618 DOI: 10.1038/s41598-020-75140-3
Abstract

Persimmon leaves are known to have some beneficial effects, including ROS elimination, lipid circulation, and neuronal protection. However, their anti-cancer properties and the underlying mechanisms remain unclear. Herein, we show that treatment with the ethanol extract of persimmon, Diospyros kaki, leaves (EEDK) induces Cancer cell death and inhibits cell proliferation. Using fluorescence resonance energy transfer (FRET) technology with genetically-encoded biosensors, we first found that EEDK stimulates a PDGFR-Rac signaling cascade in live cells. Moreover, we found that downstream of the PDGFR-Rac pathway, JNKs are activated by EEDK. In contrast, JNK-downstream inhibitors, such as CoCl2, T-5224, and pepstatin A, attenuated EEDK-induced cell death. Thus, we illustrate that the PDGFR-Rac-JNK signaling axis is triggered by EEDK, leading to Cancer cell death, suggesting the extract of persimmon leaves may be a promising anti-cancer agent.

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