2. Academic Validation
  3. Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia

Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia

  • Front Med. 2021 Jun;15(3):472-485. doi: 10.1007/s11684-021-0832-y.
Yao Yao 1,  Rui Zhou 1,  Rui Bai 2,  Jing Wang 1,  Mengjiao Tu 1,  Jingjing Shi 1,  Xiao He 1,  Jinyun Zhou 1,  Liu Feng 1,  Yuanxue Gao 1,  Fahuan Song 1,  Feng Lan 2,  Xingguo Liu 3,  Mei Tian 4,  Hong Zhang 5 6 7 8
Affiliations

Affiliations

  • 1 Department of Nuclear Medicine and PET-CT Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
  • 2 Beijing Laboratory for Cardiovascular Precision Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
  • 3 Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  • 4 Department of Nuclear Medicine and PET-CT Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China. meitian@zju.edu.cn.
  • 5 Department of Nuclear Medicine and PET-CT Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China. hzhang21@zju.edu.cn.
  • 6 Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310027, China. hzhang21@zju.edu.cn.
  • 7 Shanxi Medical University, Taiyuan, 030001, China. hzhang21@zju.edu.cn.
  • 8 The College of Biomedical Engineering and Instrument Science of Zhejiang University, Hangzhou, 310027, China. hzhang21@zju.edu.cn.
PMID: 33263836 DOI: 10.1007/s11684-021-0832-y
Abstract

Hypoxia conditioning could increase the survival of transplanted neuronal progenitor cells (NPCs) in rats with cerebral ischemia but could also hinder neuronal differentiation partly by suppressing Mitochondrial Metabolism. In this work, the Mitochondrial Metabolism of hypoxia-conditioned NPCs (hcNPCs) was upregulated via the additional administration of resveratrol, an herbal compound, to resolve the limitation of hypoxia conditioning on neuronal differentiation. Resveratrol was first applied during the in vitro neuronal differentiation of hcNPCs and concurrently promoted the differentiation, synaptogenesis, and functional development of neurons derived from hcNPCs and restored the Mitochondrial Metabolism. Furthermore, this herbal compound was used as an Adjuvant during hcNPC transplantation in a photothrombotic stroke rat model. Resveratrol promoted neuronal differentiation and increased the long-term survival of transplanted hcNPCs. 18-fluorine fluorodeoxyglucose positron emission tomography and rotarod test showed that resveratrol and hcNPC transplantation synergistically improved the neurological and metabolic recovery of stroke rats. In conclusion, resveratrol promoted the neuronal differentiation and therapeutic efficiency of hcNPCs in stroke rats via restoring Mitochondrial Metabolism. This work suggested a novel approach to promote the clinical translation of NPC transplantation therapy.

Keywords

cerebral ischemia; mitochondrial metabolism; neuronal differentiation; neuronal progenitor cells; positron emission tomography; resveratrol.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z