2. Academic Validation
  3. Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

  • Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3493-3501. doi: 10.1007/s00259-021-05343-x.
Yue Zhou  # 1 2 3,  Xin Yang  # 4 5,  Huipan Liu 1 2 3,  Wenbin Luo 6,  Hanxiang Liu 1 2 3,  Taiyong Lv 1 2 3,  Junzheng Wang 1 2 3,  Jianhua Qin 4 5,  Santao Ou 4 5,  Yue Chen 7 8 9
Affiliations

Affiliations

  • 1 Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, People's Republic of China.
  • 2 Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China, 646000.
  • 3 Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China, 646000.
  • 4 Department of Nephrology, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District. No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, People's Republic of China.
  • 5 Sichuan Clinical Research Center for Nephropathy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China, 646000.
  • 6 Department of Cardiology, Daping Hospital of The Third Military Medical University, Chongqing, People's Republic of China, 400042.
  • 7 Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, 646000, People's Republic of China. chenyue5523@126.com.
  • 8 Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China, 646000. chenyue5523@126.com.
  • 9 Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China, 646000. chenyue5523@126.com.
  • # Contributed equally.
PMID: 33829416 DOI: 10.1007/s00259-021-05343-x
Abstract

Purpose: Renal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolonging patient survival. Renal puncture examination is the gold standard for renal fibrosis, but it has several limitations. This study aims to evaluate the diagnostic performance of a novel PET radiotracer, [68Ga]Ga-fibroblast activation protein inhibitor (FAPI)-04, which specifically images fibroblast activation protein (FAP) expression for renal fibrosis.

Methods: All patients underwent renal puncture before receiving [68Ga]Ga-FAPI-04 PET/CT imaging. They then underwent [68Ga]Ga-FAPI-04 PET/CT and immunochemistry examinations. The data obtained were analyzed.

Results: The [68Ga]Ga-FAPI-04 PET/CT examination results demonstrated that almost all patients (12/13) exhibited increased radiotracer uptake. The maximum standardized uptake value (SUVmax) in patients with mild, moderate, and severe fibrosis was 3.92 ± 1.50, 5.98 ± 1.6, and 7.67 ± 2.23, respectively.

Conclusion: Compared with renal puncture examination, non-invasive imaging of FAP expression through [68Ga]Ga-FAPI-04 PET/CT quickly demonstrates bilateral kidney conditions with high sensitivity. [68Ga]Ga-FAPI-04 PET/CT can facilitate the evaluation of disease progression, diagnosis, and the development of a treatment plan.

Keywords

PET/CT; Renal fibrosis; Renal puncture; [68Ga]Ga-FAPI.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-128643
    98.42%, FAP抑制剂
    FAP
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